As I mentioned in part 11 of my MASSIVE CHALICE playthrough, relic weapons are a bit of an issue with me.
Then along game Winter Gisling, a talented Hunter hailing from the upper branch of House Gisling. I equipped her with Clock Ticker, the family relic weapon, and [spoiler alert] smashed the Cadence into silence.
It was glorious. With every kill, not only did she gain experience, but so did the Clock Ticker. By the end, it was a considerably more powerful weapon than when she first held it.
I then made the mistake of retiring her, preventing any of her clan from using the weapon for the next 50 years.